Researchers at Nottingham University might have found the answer to developing an alternative treatment for the potentially fatal Long QT syndrome. By using patients skin samples, Professor Chris Denning has successfully produced stem cells, which were then transformed into heart cells. These heart cells contain the genetic predisposition that causes long QT, meaning that the effects of new drugs can be studied in the laboratory. Researchers hope that this technique can be used to help develop new treatments for the syndrome.
Long QT syndrome affects electrical activity within the heart, resulting in the sudden onset of potentially fatal arrhythmias in response to anxiety or exercise. The syndrome is currently treated with beta-blockers, however if medication does not work then a small device known as an implantable cardioverter defibrillator (ICD) is fitted. Neither treatment path is perfect and both have side-effects, which is why the new research is so important.
The research, which is backed by the British Heart Foundation and Heart Research UK is still in its infancy but seems promising. Indications have already shown the heart cells to have the same electrical activity as found in a whole heart.